Increased apoptotic cells in bone marrow biopsies from patients with aplastic anaemia

被引：31

作者：

Callera, F ^{[1
]}

Falcao, RP ^{[1
]}

机构：

[1] DEPT CLIN MED,SCH MED,BR-14049900 RIBEIRAO PRET,SP,BRAZIL

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 01期

关键词：

aplastic anaemia; apoptosis; bone marrow biopsy; stem cells; TUNEL method;

D O I：

10.1046/j.1365-2141.1997.1532971.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In order to investigate the involvement of apoptosis in the pathogenesis of aplastic anaemia (AA) we determined the proportion of apoptotic cells in paraffin-embedded bone marrow biopsies from patients with aplastic anaemia using an in situ TdT-catalysed DNA nick end labelling (TUNEL) staining method. A significant increase in the proportion of mononuclear apoptotic cells was demonstrated in biopsies from patients with aplastic anaemia (8.19 +/- 1.45%) when compared with controls (2.07 +/- 0 86%). These data support the view that apoptosis may play a role in the pathophysiology of bone marrow failure.

引用

页码：18 / 20

页数：3

共 10 条

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