学术探索
学术期刊
新闻热点
数据分析
智能评审

Pathogenesis of hepatitis B virus infection

被引：100
作者：
Baumert, Thomas F.
Thimme, Robert
von Weizsaecker, Fritz
机构：
[1] Humboldt Univ, Teaching Hosp Charite, Dept Med 1, Schlosspk Klin, D-14059 Berlin, Germany
[2] Univ Freiburg, Dept Med 2, D-7800 Freiburg, Germany
[3] Univ Strasbourg, INSERM U748, F-67000 Strasbourg, France
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 01期
关键词：
host response; viral hepatitis; mutants; pathogenesis; resistance;
D O I：
10.3748/wjg.v13.i1.82
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Infection with hepatitis B virus (HBV) leads to a wide spectrum of clinical presentations ranging from an asymptomatic carrier state to self-limited acute or fulminant hepatitis to chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma. Infection with HBV is one of the most common viral diseases affecting man. Both viral factors as well as the host immune response have been implicated in the pathogenesis and clinical outcome of HBV infection. In this review, we will discuss the impact of virus-host interactions for the pathogenesis of HBV infection and liver disease. These interactions include the relevance of naturally occurring viral variants for clinical disease, the role of virus-induced apoptosis for HBV-induced liver cell injury and the impact of antiviral immune responses for outcome of infection. (c) 2007 The WJG Press. All rights reserved.
引用
收藏
页码：82 / 90
页数：9
相关论文
共 120 条
[1]   CHRONIC ACTIVE HEPATITIS WITH HEPATITIS-B VIRUS-DNA AND ANTIBODY AGAINST E-ANTIGEN IN THE SERUM - DISTURBED SYNTHESIS AND SECRETION OF E-ANTIGEN FROM HEPATOCYTES DUE TO A POINT MUTATION IN THE PRECORE REGION [J].
AKAHANE, Y ;
YAMANAKA, T ;
SUZUKI, H ;
SUGAI, Y ;
TSUDA, F ;
YOTSUMOTO, S ;
OMI, S ;
OKAMOTO, H ;
MIYAKAWA, Y ;
MAYUMI, M .
GASTROENTEROLOGY, 1990, 99 (04) :1113-1119
[2]   Identification and characterization of mutations in hepatitis B virus resistant to lamivudine [J].
Allen, MI ;
Deslauriers, M ;
Andrews, CW ;
Tipples, GA ;
Walters, KA ;
Tyrrell, DLJ ;
Brown, N ;
Condreay, LD .
HEPATOLOGY, 1998, 27 (06) :1670-1677
[3]   Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase [J].
Angus, P ;
Vaughan, R ;
Xiong, S ;
Yang, HL ;
Delaney, W ;
Gibbs, C ;
Brosgart, C ;
Colledge, D ;
Edwards, R ;
Ayres, A ;
Bartholomeusz, A ;
Locarnini, S .
GASTROENTEROLOGY, 2003, 125 (02) :292-297
[4]   THE AMINO-TERMINAL DOMAIN OF THE HEPADNAVIRAL P-GENE ENCODES THE TERMINAL PROTEIN (GENOME-LINKED PROTEIN) BELIEVED TO PRIME REVERSE TRANSCRIPTION [J].
BARTENSCHLAGER, R ;
SCHALLER, H .
EMBO JOURNAL, 1988, 7 (13) :4185-4192
[5]   Hepatitis B virus mutants and fulminant hepatitis B: Fitness plus phenotype [J].
Bartholomeusz, A ;
Locarnini, S .
HEPATOLOGY, 2001, 34 (02) :432-435
[6]   Variants of two major T cell epitopes within the hepatitis B surface antigen are not recognized by specific T helper cells of vaccinated individuals [J].
Bauer, T ;
Weinberger, K ;
Jilg, W .
HEPATOLOGY, 2002, 35 (02) :455-465
[7]  
Baumert T F, 2005, Minerva Gastroenterol Dietol, V51, P95
[8]   Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication [J].
Baumert, TF ;
Rogers, SA ;
Hasegawa, K ;
Liang, TJ .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (10) :2268-2276
[9]   A novel target of hepatitis B virus mutations:: Splicing of surface RNA [J].
Baumert, TF ;
Köck, J ;
Blum, HE .
HEPATOLOGY, 2005, 42 (01) :21-23
[10]   Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes [J].
Baumert, TF ;
Yang, C ;
Schürmann, P ;
Köck, J ;
Ziegler, C ;
Grüllich, C ;
Nassal, M ;
Liang, TJ ;
Blum, HE ;
von Weizsäcker, F .
HEPATOLOGY, 2005, 41 (02) :247-256
12345678910