Lipids on the move: phosphoinositide 3-kinases in leukocyte function

被引:109
作者
Wymann, MP [1 ]
Sozzani, S
Altruda, F
Mantovani, A
Hirsch, E
机构
[1] Univ Fribourg, Inst Biochem, CH-1700 Fribourg, Switzerland
[2] Ist Ric Farmacol Mario Negri, Milan, Italy
[3] Univ Turin, Dept Genet Biol & Biochem, I-10126 Turin, Italy
[4] Univ Brescia, Sect Gen Pathol, Brescia, Italy
来源
IMMUNOLOGY TODAY | 2000年 / 21卷 / 06期
关键词
D O I
10.1016/S0167-5699(00)01649-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
All four known cell surface receptor-activated phosphoinositide 3-kinases have been found in leukocytes. Matthias Wymann and colleagues discuss their nonredundant roles in leukocyte function, particularly in chemotaxis, and their promise as targets for therapeutic intervention.
引用
收藏
页码:260 / 264
页数:5
相关论文
共 48 条
  • [1] Al-Aoukaty A, 1999, J IMMUNOL, V162, P3249
  • [2] WORTMANNIN IS A POTENT PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR - THE ROLE OF PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE IN NEUTROPHIL RESPONSES
    ARCARO, A
    WYMANN, MP
    [J]. BIOCHEMICAL JOURNAL, 1993, 296 : 297 - 301
  • [3] INHIBITION OF THE PHAGOCYTOSIS-INDUCED RESPIRATORY BURST BY THE FUNGAL METABOLITE WORTMANNIN AND SOME ANALOGS
    BAGGIOLINI, M
    DEWALD, B
    SCHNYDER, J
    RUCH, W
    COOPER, PH
    PAYNE, TG
    [J]. EXPERIMENTAL CELL RESEARCH, 1987, 169 (02) : 408 - 418
  • [4] Baier R, 1999, CELL GROWTH DIFFER, V10, P447
  • [5] FC RECEPTOR STIMULATION OF PHOSPHATIDYLINOSITOL 3-KINASE IN NATURAL-KILLER-CELLS IS ASSOCIATED WITH PROTEIN-KINASE C-INDEPENDENT GRANULE RELEASE AND CELL-MEDIATED CYTOTOXICITY
    BONNEMA, JD
    KARNITZ, LM
    SCHOON, RA
    ABRAHAM, RT
    LEIBSON, PJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) : 1427 - 1435
  • [6] Signalling enzymes: Bursting with potential
    Braselmann, S
    Palmer, TM
    Cook, SJ
    [J]. CURRENT BIOLOGY, 1997, 7 (08) : R470 - R473
  • [7] Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
    Burger, JA
    Burger, M
    Kipps, TJ
    [J]. BLOOD, 1999, 94 (11) : 3658 - 3667
  • [8] Chantry D, 1999, BLOOD, V94, P1890
  • [9] Coffer PJ, 1998, BIOCHEM J, V329, P121
  • [10] Of man and mouse: Leukocyte and endothelial adhesion molecule deficiencies
    Etzioni, A
    Doerschuk, CM
    Harlan, JM
    [J]. BLOOD, 1999, 94 (10) : 3281 - 3288