UniProt: the universal protein knowledgebase in 2021

被引：3602

作者：

Bateman, Alex ^{[1
,2
]}

Martin, Maria-Jesus ^{[2
]}

Orchard, Sandra ^{[2
]}

Magrane, Michele ^{[2
]}

Agivetova, Rahat ^{[2
]}

Ahmad, Shadab ^{[2
]}

Alpi, Emanuele ^{[2
]}

Bowler-Barnett, Emily H. ^{[2
]}

Britto, Ramona ^{[2
]}

Bursteinas, Borisas ^{[2
]}

Bye-A-Jee, Hema ^{[2
]}

Coetzee, Ray ^{[2
]}

Cukura, Austra ^{[2
]}

Da Silva, Alan ^{[2
]}

Denny, Paul ^{[2
]}

Dogan, Tunca ^{[2
]}

Ebenezer, ThankGod ^{[2
]}

Fan, Jun ^{[2
]}

Castro, Leyla Garcia ^{[2
]}

Garmiri, Penelope ^{[2
]}

Georghiou, George ^{[2
]}

Gonzales, Leonardo ^{[2
]}

Hatton-Ellis, Emma ^{[2
]}

Hussein, Abdulrahman ^{[2
]}

Ignatchenko, Alexandr ^{[2
]}

Insana, Giuseppe ^{[2
]}

Ishtiaq, Rizwan ^{[2
]}

Jokinen, Petteri ^{[2
]}

Joshi, Vishal ^{[2
]}

Jyothi, Dushyanth ^{[2
]}

Lock, Antonia ^{[2
]}

Lopez, Rodrigo ^{[2
]}

Luciani, Aurelien ^{[2
]}

Luo, Jie ^{[2
]}

Lussi, Yvonne ^{[2
]}

Mac-Dougall, Alistair ^{[2
]}

Madeira, Fabio ^{[2
]}

Mahmoudy, Mahdi ^{[2
]}

Menchi, Manuela ^{[2
]}

Mishra, Alok ^{[2
]}

Moulang, Katie ^{[2
]}

Nightingale, Andrew ^{[2
]}

Oliveira, Carla Susana ^{[2
]}

Pundir, Sangya ^{[2
]}

Qi, Guoying ^{[2
]}

Raj, Shriya ^{[2
]}

Rice, Daniel ^{[2
]}

Lopez, Milagros Rodriguez ^{[2
]}

Saidi, Rabie ^{[2
]}

Sampson, Joseph ^{[2
]}

机构：

[1] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Wellcome Genome Campus, Hinxton CB10 ISD, England

[2] EMBL European Bioinformat Inst, Cambridge, England

[3] SIB Swiss Inst Bioinformat, Ctr Med Univ, 1 Rue Michel Servet, CH-1211 Lausanne 4, Switzerland

[4] Georgetown Univ, Prot Informat Resource, Med Ctr, 3300 Whitehaven St NW,Suite 1200, Washington, DC 20007 USA

[5] Univ Delaware, Prot Informat Resource, Ammon Pinizzotto Biopharmaceut Innovat Bld, Newark, DE 19713 USA

来源：

NUCLEIC ACIDS RESEARCH | 2021年 / 49卷 / D1期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院;

关键词：

ALZHEIMERS-DISEASE; TRANSCRIPTOME; PREDICTION; ANNOTATION; RESOURCES; CURATION;

D O I：

10.1093/nar/gkaa1100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.

引用

页码：D480 / D489

页数：10

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