Synthesis and biological evaluation of aristolactams

被引：63

作者：

Couture, A

Deniau, E

Grandclaudon, P

Rybalko-Rosen, H

Léonce, S

Pfeiffer, B

Renard, P

机构：

[1] UST Lille, Chim Organ Phys Lab, ESA 8009, CNRS, F-59655 Villeneuve Dascq, France

[2] Inst Rech Servier, Div Cancerol Expt, F-92150 Suresnes, France

[3] SERVIER, F-92415 Courbevoie, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(02)00794-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3557 / 3559

页数：3

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