Solid phase synthesis of sec-amides and removal from the polymeric support under mild conditions

被引：42

作者：

Sarantakis, D

Bicksler, JJ

机构：

[1] Medicinal Chemistry Department, Wyeth-Ayerst Research, CN 8000, Princeton

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(97)01779-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-terminal sec-amides of peptidic and non-peptidic carboxylic acids can be prepared using 2-methoxy-4-benzyloxy-polystyrene aldehyde resin (MALDRE). The polymer bound sec-amide is removed from the resin by treatment with 10-50% trifluoroacetic acid in methylene dichloride for 30 minutes. (C) 1997 Elsevier Science Ltd.

引用

页码：7325 / 7328

页数：4

共 9 条

[1]

ALBERICIO F, 1987, INT J PEPT PROT RES, V30, P206

[2] Solid-phase synthesis of 1,4-benzodiazepine-2,5-diones. Library preparation and demonstration of synthesis generality [J].