ETV6-NTRK3 - Trk-ing the primary event in human secretory breast cancer

被引：40

作者：

Euhus, DM

Timmons, CF

Tomlinson, GE

机构：

[1] Univ Texas, SW Med Ctr, Dept Surg, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75390 USA

来源：

CANCER CELL | 2002年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(02)00184-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Tognon et al. (2002) propose a single chromosomal translocation as the cause of a particularly troubling form of breast cancer, secretory carcinoma. They challenge widely held beliefs concerning breast carcinogenesis as well as beliefs concerning the absolute association of specific fusion genes with specific tumor types. Their data highlight the role of Trk signaling in breast cancer and also suggest a target for drug development.

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收藏

页码：347 / 348

页数：2

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