Adenoviral vectors: Systemic delivery and tumor targeting

被引：71

作者：

Green, NK ^{[1
]}

Seymour, LW ^{[1
]}

机构：

[1] Univ Oxford, Radcliffe Infirm, Dept Clin Pharmacol, Oxford OX2 6HE, England

来源：

CANCER GENE THERAPY | 2002年 / 9卷 / 12期

关键词：

adenovirus; gene delivery; gene therapy; pharmacokinetics; tumor targeting; virus retargeting;

D O I：

10.1038/sj.cgt.7700541

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The development of a targeted adenoviral vector, which can be delivered systemically, is one of the major challenges facing cancer gene therapy. The virus is readily cleared from the bloodstream, can be neutralised by pre-existing antibodies, and has a permissive cellular tropism. Clinical studies using the ONYX virus have shown limited efficacy, but there are several hurdles to overcome to achieve an effective tumor-specific systemic therapy. In this review, we have summarized the various used to overcome the limitations of adenoviral-mediated gene delivery.

引用

页码：1036 / 1042

页数：7

共 60 条

[1] Blood clearance rates of adenovirus type 5 in mice [J].

Alemany, R ;

Suzuki, K ;

Curiel, DT .

JOURNAL OF GENERAL VIROLOGY, 2000, 81 :2605-2609

[2] CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors [J].

Alemany, R ;

Curiel, DT .

GENE THERAPY, 2001, 8 (17) :1347-1353

[3] ADENOVIRUS PROTEINS FROM BOTH E1B READING FRAMES ARE REQUIRED FOR TRANSFORMATION OF RODENT CELLS BY VIRAL-INFECTION AND DNA TRANSFECTION [J].

BARKER, DD ;

BERK, AJ .

VIROLOGY, 1987, 156 (01) :107-121

[4] p14ARF links the tumour suppressors RB and p53 [J].

Bates, S ;

Phillips, AC ;

Clark, PA ;

Stott, F ;

Peters, G ;

Ludwig, RL ;

Vousden, KH .

NATURE, 1998, 395 (6698) :124-125

[5] Recombinant adenovirus gene transfer in adults with partial ornithine transcarbamylase deficiency (OTCD) [J].

Batshaw, ML ;

Wilson, JM ;

Raper, S .

HUMAN GENE THERAPY, 1999, 10 (14) :2419-2437

[6] Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5 [J].

Bergelson, JM ;

Cunningham, JA ;

Droguett, G ;

KurtJones, EA ;

Krithivas, A ;

Hong, JS ;

Horwitz, MS ;

Crowell, RL ;

Finberg, RW .

SCIENCE, 1997, 275 (5304) :1320-1323

[7] The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses [J].

Bergelson, JM ;

Krithivas, A ;

Celi, L ;

Droguett, G ;

Horwitz, MS ;

Wickham, T ;

Crowell, RL ;

Finberg, RW .

JOURNAL OF VIROLOGY, 1998, 72 (01) :415-419

[8] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J].

Bischoff, JR ;

Kim, DH ;

Williams, A ;

Heise, C ;

Horn, S ;

Muna, M ;

Ng, L ;

Nye, JA ;

SampsonJohannes, A ;

Fattaey, A ;

McCormick, F .

SCIENCE, 1996, 274 (5286) :373-376

[9] Retargeting to EGFR enhances adenovirus infection efficiency of squamous cell carcinoma [J].

Blackwell, JL ;

Miller, CR ;

Douglas, JT ;

Li, H ;

Reynolds, PN ;

Carroll, WR ;

Peters, GE ;

Strong, TV ;

Curiel, DT .

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 1999, 125 (08) :856-863

[10] THE LUNG-SPECIFIC SURFACTANT PROTEIN-B GENE PROMOTER IS A TARGET FOR THYROID TRANSCRIPTION FACTOR-1 AND HEPATOCYTE NUCLEAR FACTOR-3, INDICATING COMMON FACTORS FOR ORGAN-SPECIFIC GENE-EXPRESSION ALONG THE FOREGUT AXIS [J].

BOHINSKI, RJ ;

DILAURO, R ;

WHITSETT, JA .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (09) :5671-5681

← 1 2 3 4 5 6 →