Human epicardium: ultrastructural ancestry of mesothelium and mesenchymal cells

被引：25

作者：

Gherghiceanu, Mihaela ^{[2
]}

Popescu, L. M. ^{[1
,2
]}

机构：

[1] Carol Davila Univ Med & Pharm, Dept Cellular & Mol Med, Bucharest 35, Romania

[2] Victor Babes Natl Inst Pathol, Bucharest, Romania

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2009年 / 13卷 / 9A期

关键词：

(sub)epicardium; epithelial-mesenchymal transition (EMT); isolated smooth muscle cells; interstitial Cajal-like cells (ICLCs); mesothelial cells; mesenchymal cells; cardiac regeneration; ICLC; MYOCARDIUM;

D O I：

10.1111/j.1582-4934.2009.00869.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The human sub-epicardial area contains an unexplored cellular population under a layer of mesothelial cells. Transmission electron microscopy revealed the existence of interstitial Cajal-like cells (ICLCs), isolated smooth muscle cells (iSMC) and mesenchymal cells besides other well-known cells. The presence of iSMC in the sub-epicardial space is quite unique and could explain why epicardial-derived cells isolated from human epicardium generate smooth muscle cells in culture. Mesenchymal cells, guided by ICLCs, were found migrating from sub-epicardial area in the mesothelial layer. These findings suggest that epithelial-mesenchymal transition is not a common process involved in cardiac regeneration in vivo.

引用

页码：2949 / 2951

页数：3

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