Dynamics-modulated biological activity of transforming growth factor β3

被引：32

作者：

Bocharov, EV

Korzhnev, DM

Blommers, MJJ ^{[1
]}

Arvinte, T

Orekhov, VY

Billeter, M

Arseniev, AS

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

[2] Russian Acad Sci, Shemyakin Ovchinnikow Inst Bioorgan Chem, Moscow, Russia

[3] Univ Gothenburg, Swedish NMR Ctr, S-40530 Gothenburg, Sweden

[4] Univ Gothenburg, Lundberg Lab, S-40530 Gothenburg, Sweden

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2002年 / 277卷 / 48期

关键词：

D O I：

10.1074/jbc.M206274200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor beta3 (TGF-beta3) is an important mediator of growth, maintenance, and repair processes in human cells. Internal dynamic properties have been derived from N-15 NMR relaxation data and mapped onto the spatial structure of TGF-beta3. The pattern of internal dynamics in the structure identifies potential "hot spots" of binding free energy and reveals the importance of conformational entropy in the interaction of TGF-beta3 with the receptors. The observed internal dynamics set TGF-beta3 apart from other TGF-beta isoforms, with which it shares the same fold. These findings may explain functional differences among the various TGF-beta isoforms and thus prove essential in the search for related therapeutic agents.

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页码：46273 / 46279

页数：7

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