Zebrafish gastrulation movements: bridging cell and developmental biology

被引：28

作者：

Heisenberg, CP

Tada, M

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[2] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 06期

基金：

英国医学研究理事会;

关键词：

gastrulation; convergent extension; cell polarity; zebrafish;

D O I：

10.1016/S1084952102001003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements.

引用

页码：471 / 479

页数：9

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