Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

被引：18

作者：

Murakami, M ^{[1
]}

Nakagawasai, O

Fujii, S

Hosono, M

Hozumi, S

Esashi, A

Taniguchi, R

Okamura, T

Suzuki, T

Sasano, H

Yanagisawa, T

Tan-No, K

Tadano, T

Kitamura, K

Kisara, K

机构：

[1] Tohoku Univ, Sch Med, Dept Mol Pharmacol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Fujirebio Inc, Pharmaceut Res Labs, Sendai, Miyagi, Japan

[3] Tohoku Pharmaceut Univ, Dept Pharmacol, Sendai, Miyagi, Japan

[4] Tohoku Univ, Sch Med, Dept Pathol, Sendai, Miyagi 980, Japan

[5] Fukuoka Dent Coll, Dept Pharmacol, Fukuoka, Japan

来源：

BRAIN RESEARCH | 2000年 / 868卷 / 01期

关键词：

calcium channel; cilnidipine; nociception;

D O I：

10.1016/S0006-8993(00)02295-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：123 / 127

页数：5

共 20 条

[1] CLASSES OF CALCIUM CHANNELS IN VERTEBRATE CELLS [J].

BEAN, BP .

ANNUAL REVIEW OF PHYSIOLOGY, 1989, 51 :367-384

[2] Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation [J].

Diaz, A ;

Dickenson, AH .

PAIN, 1997, 69 (1-2) :93-100

[3]

ELLIOTT EM, 1995, J NEUROSCI, V15, P6433

[4]

FLECKENSTEIN A, 1963, CALCIUM ANTAGONISTS

[5] SINGLE-CHANNEL RECORDINGS OF 3 TYPES OF CALCIUM CHANNELS IN CHICK SENSORY NEURONS [J].

FOX, AP ;

NOWYCKY, MC ;

TSIEN, RW .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 394 :173-200

[6]

Fujii S, 1997, J PHARMACOL EXP THER, V280, P1184

[7] NEUROANATOMICAL DISTRIBUTION OF RECEPTORS FOR A NOVEL VOLTAGE-SENSITIVE CALCIUM-CHANNEL ANTAGONIST, SNX-230 (OMEGA-CONOPEPTIDE-MVIIC) [J].

GOHIL, K ;

BELL, JR ;

RAMACHANDRAN, J ;

MILJANICH, GP .

BRAIN RESEARCH, 1994, 653 (1-2) :258-266

[8]

GRUNER W, 1994, J NEUROSCI, V14, P2800

[9]

HILLYARD DR, 1992, NEURON, V9, P67

[10]

HOFMANN F, 1994, ANNU REV NEUROSCI, V17, P399, DOI 10.1146/annurev.ne.17.030194.002151

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