Bioactive phenolic derivatives from Acaena splendens methanol extract

被引:17
作者
Backhouse, N
Delporte, C
Negrete, R
San Feliciano, SA
López-Pérez, JL
机构
[1] Univ Chile, Fac Chem & Pharmaceut Sci, Pharmacognosy Lab, Santiago 1, Chile
[2] Univ Salamanca, Fac Pharm, Dept Organ & Pharmaceut Chem, Salamanca 37007, Spain
关键词
Acaena splendens; antiinflammatory; antipyretic activities; flavonoids; chromone;
D O I
10.1002/ptr.997
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Acaena splendens H. et A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the in vivo reduction of bacterial pyrogen-induced fever in rabbits and carrageenan-induced paw oedema in guinea pigs is presented. The methanol extract named ME-1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassayguided fractionation by column chromatography afforded the active fraction, which contained (-,-)-epicatechin, tiliroside, 7-O-acetyl-3-O-beta-D-glucosyl-kaempferol and 7-beta-D-glucosyloxy-5-hydroxy-chromone. Copyright (C) 2002 John Wiley Sons, Ltd.
引用
收藏
页码:562 / 566
页数:5
相关论文
共 20 条
[1]   MODIFICATION OF ARACHIDONIC METABOLISM BY FLAVONOIDS [J].
ALCARAZ, MJ ;
FERRANDIZ, ML .
JOURNAL OF ETHNOPHARMACOLOGY, 1987, 21 (03) :209-229
[2]  
Backhouse N., 1994, International Journal of Pharmacognosy, V32, P239, DOI 10.3109/13880209409083000
[3]   Antiinflammatory and antipyretic metabolites of Acaena splendens [J].
Backhouse, N ;
Delporte, C ;
Negrete, R ;
Suarez, S ;
Cassels, BK ;
Breitmaier, E ;
Schneider, C .
INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1997, 35 (01) :49-54
[4]  
BREITMAIER E, 1993, STRUCTURE ELUCIDATIO, P176
[5]   STRUCTURE ELUCIDATION AND SYNTHESIS OF NATURALLY OCCURRING ACYLGLYCOSIDES - II1 - STRUCTURES OF TILIROSIDE, TRIBULOSIDE, AND IPOMINE [J].
CHARI, VM ;
JORDAN, M ;
WAGNER, H .
PLANTA MEDICA, 1978, 34 (01) :93-96
[6]  
FUNFGELD EW, 1988, RECENTS RESULTS PHAR, P365
[7]  
HARBORNE JB, 1982, FLAVONOIDS ADV RES, V56, P53
[8]  
Jung KY, 1998, BIOL PHARM BULL, V21, P1077, DOI 10.1248/bpb.21.1077
[9]   INTERPRETATION OF RESEARCH DATA - ANALYSIS OF VARIANCE [J].
KOHOUT, FJ ;
NORWOOD, GJ .
AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1981, 38 (01) :96-&
[10]  
KUROYANAGI M, 1978, CHEM PHARM BULL, V26, P3594