Age-related white matter changes and cognitive impairment

被引：41

作者：

Ferro, JM ^{[1
]}

Madureira, S ^{[1
]}

机构：

[1] Hosp Santa Maria, Ctr Estudos Egas Moniz, Neurol Serv, P-1649035 Lisbon, Portugal

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2002年 / 203卷

关键词：

white matter; leukoaraiosis; dementia; cognition; stroke; neuropsychology;

D O I：

10.1016/S0022-510X(02)00295-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Age-related white matter changes (WMC) are a frequent finding in CT/MRI of older subjects. The role of WMC in cognitive impairment has been studied in community-dwelling and healthy old people, subjects with vascular risk factors, stroke patients, depressed and demented subjects. Although there are several negative studies, the majority of the evidence points towards an association between WMC and cognitive impairment. Speed of mental processes, attention, concentration, executive functions and visual spatial skills are the cognitive domains more commonly affected. The methodological problems of the negative studies are discussed, a number of unsolved issues are raised stressing the need for longitudinal studies of WMC with a adequate inception cohort. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：221 / 225

页数：5

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