Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers

被引：44

作者：

Hillaireau, H.

Le Doan, T.

Chacun, H.

Janin, J.

Couvreur, P.

机构：

[1] Univ Paris Sud, UMR 8612, CNRS, F-92296 Chatenay Malabry, France

[2] CNRS, UMR 8612, F-92296 Chatenay Malabry, France

[3] CNRS, UPR 9063, F-91198 Gif Sur Yvette, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2007年 / 331卷 / 02期

关键词：

poly(alkylcyanoacrylate); nanocapsules; azidothymidine-triphosphate; cidofovir; oligonucleotides;

D O I：

10.1016/j.ijpharm.2006.10.031

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In a previous study, we have shown that cidofovir (CDV) and azidothymidine-triphosphate (AZT-TP) were poorly encapsulated in poly(isobutylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and hydrophilic molecules through the thin polymer wall of the nanocapsules. In the present study, we have selected various water-soluble polymers as increasing Mw adjuvants and investigated their influence on the entrapment of mononucleotides (CDV, AZT-TP) as well as of oligonucleotides (ODN) into these PIBCA aqueous-core nanocapsules. We show here that the presence of cationic polymers (i.e. poly(ethyleneimine) (PEI) or chitosan) in the nanocapsule aqueous compartment allowed successful encapsulation of AZT-TP and ODN. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：148 / 152

页数：5

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