Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2= salicylic acid)

被引：89

作者：

Coyle, B

McCann, M ^{[1
]}

Kavanagh, K

Devereux, M

McKee, V

Kayal, N

Egan, D

Deegan, C

Finn, GJ

机构：

[1] Natl Univ Ireland Maynooth, Dept Chem, Maynooth, Kildare, Ireland

[2] Natl Univ Ireland Maynooth, Dept Biol, Maynooth, Kildare, Ireland

[3] Dublin Inst Technol, Dublin 8, Ireland

[4] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

[5] Dublin Inst Technol, Dept Appl Sci, Dublin 24, Ireland

[6] Harvard Univ, Sch Med, Inst Med, Beth Israel Deaconess Med Ctr,Canc Res Program, Boston, MA 02115 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2004年 / 98卷 / 08期

关键词：

silver(I); salicylate; X-ray structure; anti-fungal; anti-cancer;

D O I：

10.1016/j.jinorgbio.2004.04.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[Ag-2(NH3)(2)(salH)(2)] (salH(2) = salicylic acid) was synthesised from salicylic acid and Ag2O in concentrated aqueous NH3 and the dimeric Ag(I) complex was characterised using X-ray crystallography. The complex is centrosymmetric with each metal coordinated to a salicylate carboxylate oxygen and to an ammonia nitrogen atom in an almost linear fashion. The two [Ag(NH3)(salH)] units in the complex are linked by an Ag-Ag bond. Whilst metal-free salH(2) did not prevent the growth of the fungal pathogen Candida albicans [Ag-2(NH3)(2)(salH)(2)], [Ag-2(salH)(2)] and some simple Ag(I) salts greatly inhibited cell reproduction. SalH(2), [Ag-2(NH3)(2)(salH)(2)] [Ag-2(salH)(2)] and AgClO4 produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1361 / 1366

页数：6

共 23 条

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