A facile synthesis of highly water-soluble, core-shell organo-silica nanoparticles with controllable size via sol-gel process

被引：33

作者：

Du, Hongwei ^{[1
,2
]}

Hamilton, Paul D. ^{[1
]}

Reilly, Matthew A. ^{[1
,2
,3
]}

d'Avignon, Andre ^{[4
]}

Biswas, Pramit ^{[3
]}

Ravi, Nathan ^{[1
,2
,3
]}

机构：

[1] Washington Univ, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA

[2] Vet Affairs Med Ctr, Dept Med Res, St Louis, MO 63106 USA

[3] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA

[4] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2009年 / 340卷 / 02期

关键词：

Organic silica; Nanoparticles; Sol-gel; Core-shell; Water-soluble; SI-29; NMR; POLY(ETHYLENE GLYCOL); SURFACE MODIFICATION; MONODISPERSE; CONDENSATION;

D O I：

10.1016/j.jcis.2009.08.032

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

A series of highly water-soluble organo-silica nanoparticles, ranging from 2 to 10 nm in diameter, were synthesized by the cohydrolysis and copolycondensation reactions. omega-methoxy(polyethyleneoxy)propyltrimethoxysilane (PEG6-9) and hydroxymethyltriethoxysilane (HMTEOS) mixtures were catalyzed by sodium hydroxide in the presence of surfactant benzethonium chloride (BTC) with various ratios of PEG6-9/HMTEOS at room temperature. The synthesized organo-silica nanoparticles possess a core-shell Structure with a core of organo-silica resulting from HMTEOS and a monolayer shell of PEG6-9. The chemo-physical characteristics of the particles were studied by gel permeation chromatography (GPC) Fourier transform infrared (FTIR) spectroscopy, Si-29 nuclear magnetic resonance (NMR), dynamic light scattering (DLS), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). The molecular weight and particle size of the particles increased with increasing HMTEOS molar ratios. The richest HMTEOS composition for the water-soluble particles was found to be HMTEOS:PEG6-9 = 80:20, where the Particles had a 6 nm diameter core and a 0.8 nm thick shell. We propose that these water-soluble organo-silica nanoparticles will be suitable for biomedical applications. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：202 / 208

页数：7

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