Serum anti-GAGA4 IgM antibodies differentiate relapsing remitting and secondary progressive multiple sclerosis from primary progressive multiple sclerosis and other neurological diseases

被引：29

作者：

Brettschneider, Johannes ^{[9
]}

Jaskowski, Troy D. ^{[8
]}

Tumani, Hayrettin ^{[9
]}

Abdul, Sana ^{[9
]}

Husebye, Dee ^{[7
]}

Seraj, Haniah ^{[7
]}

Hill, Harry R. ^{[4
,5
,6
]}

Fire, Ella ^{[3
]}

Spector, Larissa ^{[3
]}

Yarden, Jennifer ^{[3
]}

Dotan, Nir ^{[3
]}

Rose, John W. ^{[1
,2
]}

机构：

[1] Univ Utah, Neurovirol Res Lab, VASLCHCS, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA

[3] Glycominds Ltd, Lod, Israel

[4] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA

[5] Univ Utah, Dept Pediat, Salt Lake City, UT 84112 USA

[6] Univ Utah, Dept Med, Salt Lake City, UT 84112 USA

[7] Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA

[8] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA

[9] Univ Ulm, Dept Neurol, D-7900 Ulm, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 217卷 / 1-2期

关键词：

Relapsing remitting multiple sclerosis; Primary progressive multiple sclerosis; Diagnosis; Anti-glucose antibodies; Serum; Enzyme immunoassay; CLINICALLY ISOLATED SYNDROMES; 1ST DEMYELINATING EVENT; DIAGNOSTIC-CRITERIA; ANTIMYELIN ANTIBODIES; MCDONALD CRITERIA; BIOMARKERS; MARKER; MRI; AUTOANTIBODIES; DISABILITY;

D O I：

10.1016/j.jneuroim.2009.07.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The serum level of IgM antibodies against Glc(alpha 1,4)Glc(alpha) (GAGA4) is higher in relapsing remitting multiple sclerosis (RRMS) compared to other neurological disease (OND) patients and healthy controls (HQ. Detecting the level of anti-GAGA4 antibody by enzyme immunoassay and total IgM, we confirmed that anti-GAGA4 IgM can differentiate RRMS from OND patients and HC Moreover, secondary progressive MS (SPMS) and RRMS patients have similar levels of anti-GAGA4 demonstrating the biomarker's presence throughout the disease. Interestingly, the anti-GAGA4 assay may also differentiate between primary progressive MS (PPMS) and RRMS/SPMS patients, since nearly all PPMS patients were negative for the assay. (C) 2009 Published by Elsevier B.V.

引用

页码：95 / 101

页数：7

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