The dual role of IL-10

被引：378

作者：

Mocellin, S

Panelli, MC

Wang, E

Nagorsen, D

Marincola, FM

机构：

[1] NIH, Ctr Clin, Dept Transfus Med, Immunogenet Sect, Bethesda, MD 20892 USA

[2] Univ Padua, Surg Branch, Dept Oncol & Surg Sci, I-35128 Padua, Italy

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 01期

关键词：

D O I：

10.1016/S1471-4906(02)00009-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability. In addition, by inhibiting the maturation of antigen-presenting cells (APCs), IL-10 preserves their ability for antigen uptake while simultaneously hampering their migration to draining lymph nodes. This review suggests that this 'antigen-loading' phase might constitute an important component of the innate immune reaction to a pathogen. Additional proinflammatory stimuli might subsequently lead to maturation of 'loaded' APCs that could migrate to draining lymph nodes or recruit and activate adaptive immune effectors locally.

引用

页码：36 / 43

页数：8

共 68 条

[1] IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response [J].