Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease

被引：37

作者：

Priori, A. ^{[1
]}

Ardolino, G.

Marceglia, S.

Mrakic-Sposta, S.

Locatelli, M.

Tamma, F.

Rossi, L.

Foffani, G.

机构：

[1] Univ Milan, Osped Policlin, Fdz IRCCS, Dipartimento Sci Neurol, Milan, Italy

[2] Osped San Paolo, Dipartimento Neurol, Milan, Italy

[3] Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA USA

来源：

BRAIN RESEARCH BULLETIN | 2006年 / 71卷 / 1-3期

关键词：

subthalamic nucleus; STN; DBS; local field potentials; LFPs; basal ganglia; human; Parkinson's disease;

D O I：

10.1016/j.brainresbull.2006.08.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change = 0.93 +/- 0.62; Wilcoxon: p = 0.0002, n = 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface. (c) 2006 Elsevier Inc. All rights reserved.

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页码：149 / 154

页数：6

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