Multidisciplinary treatment of locally advanced rectal cancer: a literature review. Part 1

被引：9

作者：

Berardi, Rossana ^{[1
]}

Maccaroni, Elena ^{[1
]}

Onofri, Azzurra ^{[2
]}

Giampieri, Riccardo ^{[2
]}

Bittoni, Alessandro ^{[2
]}

Pistelli, Mirco ^{[2
]}

Scartozzi, Mario ^{[1
]}

Pierantoni, Chiara ^{[1
]}

Bianconi, Maristella ^{[1
]}

Cascinu, Stefano ^{[1
]}

机构：

[1] Univ Politecn Marche, Azienda Osped, Univ Osped Riuniti Umberto 1, GM Lancisi G Salesi Ancona,Med Oncol Unit, I-60020 Ancona, Italy

[2] Univ Politecn Marche, Postgrad Sch Oncol, I-60126 Ancona, Italy

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2009年 / 10卷 / 14期

关键词：

locally advanced rectal cancer; neoadjuvant treatment; radiochemotherapy; target drugs; QUALITY-OF-LIFE; PREOPERATIVE RADIATION-THERAPY; TOTAL MESORECTAL EXCISION; PHASE-II; POSTOPERATIVE CHEMORADIOTHERAPY; INTERSPHINCTERIC RESECTION; PROGNOSTIC-SIGNIFICANCE; SPHINCTER PRESERVATION; SEXUAL DYSFUNCTION; RANDOMIZED-TRIAL;

D O I：

10.1517/14656560903143776

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In Western countries, colorectal cancer is the third most common cancer in terms of incidence and mortality. The management of rectal cancer has undergone and continues to undergo significant evolutions. In the last two decades, new multimodality strategies have been developed. Multimodality treatments have improved the prognosis of locally advanced rectal cancer with local recurrences decreasing from 40% to < 10% and overall survival increasing from 50% to 75% in the last 40 years. This review discusses the role of neoadjuvant chemoradiotherapy regimens used in the standard combined modality treatment programs for rectal cancer and focuses on the ongoing research to improve these regimens.

引用

页码：2245 / 2258

页数：14

共 62 条

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