The functional mechanism of simvastatin in experimental osteoporosis

被引：20

作者：

Dai, Lifen ^{[1
,2
,3
,4
]}

Xu, Ming ^{[1
]}

Wu, Haiying ^{[5
,6
]}

Xue, Lanjie ^{[7
]}

Yuan, Dekai ^{[1
]}

Wang, Yuan ^{[1
]}

Shen, Zhiqiang ^{[3
,4
]}

Zhao, Hongbin ^{[5
,6
]}

Hu, Min ^{[1
]}

机构：

[1] Kunming Univ, Kunming Res Ctr Mol Med, Kunming 650214, Peoples R China

[2] Kunming Med Univ, Affiliated Hosp 2, Dept Endocrinol, Kunming 650500, Peoples R China

[3] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China

[4] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China

[5] Kunming Med Univ, Affiliated Hosp 1, Dept Emergency Med, Kunming 650032, Peoples R China

[6] Kunming Med Univ, Affiliated Hosp 1, Intens Care Unit, Kunming 650032, Peoples R China

[7] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China

来源：

JOURNAL OF BONE AND MINERAL METABOLISM | 2016年 / 34卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Simvastatin; Osteoporosis; Osteoblast; Bone mineral density; Animal model; BONE MORPHOGENETIC PROTEIN-2; COA REDUCTASE INHIBITORS; OSTEOBLAST DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; ANABOLIC THERAPIES; PROLIFERATION; EXPRESSION; STATINS; RISK; MICROARCHITECTURE;

D O I：

10.1007/s00774-014-0638-y

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use of animal models, the treatment effectiveness of simvastatin on experimental osteoporosis was investigated and the functional mechanism was preliminarily explored. The results show that simvastatin significantly increased the mechanical parameters such as maximum load, stiffness, and energy-absorbing capacity, and improved the microarchitecture. They indicated that the antiosteoporosis activity of simvastatin may be due to the promotion of proliferation and differentiation of osteoblasts. Simvastatin was effective in treating experimental osteoporosis. This study provides necessary experimental evidence for the clinical application of simvastatin in osteoporosis treatment.

引用

页码：23 / 32

页数：10

共 51 条

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