Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR

被引：20

作者：

Chinetti, G.

Fruchart, J. C.

Staels, B.

机构：

[1] Inst Pasteur, INSERM, U545, F-59019 Lille, France

[2] Univ Lille 2, Fac Pharm, F-59006 Lille, France

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

cholesterol; liver X receptor (LXR); macrophage; peroxisome-proliferator-activated receptor alpha (PPAR alpha); trafficking; transcriptional regulation;

D O I：

10.1042/BST0341128

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PPARs (peroxisome-proliferator-activated receptors) and LXRs (liver X receptors) are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Since the macrophage plays an important role in host defence and immuno-inflammatory pathologies, particular attention has been paid to the role of PPARs and LXRs in the control of macrophage gene expression and function. Altered macrophage functions contribute to the pathogenesis of many infectious, immunological and inflammatory disease processes, including atherosclerosis. Research over the last few years has revealed important roles for PPARs and LXRs in macrophage inflammation and cholesterol homoeostasis. with consequences in atherosclerosis development. This review will discuss the role of these transcription factors in the control of cholesterol trafficking in macrophages.

引用

页码：1128 / 1131

页数：4

共 35 条

[1] Activation of peroxisome proliferator-activated receptor gamma and retinoid X receptor results in net depletion of cellular cholesteryl esters in macrophages exposed to oxidized lipoproteins [J].

Argmann, CA ;

Sawyez, CG ;

McNeil, CJ ;

Hegele, RA ;

Huff, MW .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (03) :475-482

[2] TYPE-C NIEMANN-PICK DISEASE - LOW-DENSITY LIPOPROTEIN UPTAKE IS ASSOCIATED WITH PREMATURE CHOLESTEROL ACCUMULATION IN THE GOLGI-COMPLEX AND EXCESSIVE CHOLESTEROL STORAGE IN LYSOSOMES [J].

BLANCHETTEMACKIE, EJ ;

DWYER, NK ;

AMENDE, LM ;

KRUTH, HS ;

BUTLER, JD ;

SOKOL, J ;

COMLY, ME ;

VANIER, MT ;

AUGUST, JT ;

BRADY, RO ;

PENTCHEV, PG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :8022-8026

[3] Mammalian acyl-CoA: cholesterol acyltransferases [J].

Buhman, KF ;

Accad, M ;

Farese, RV .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1529 (1-3) :142-154

[4]

BUTLER JD, 1992, J BIOL CHEM, V267, P23797

[5] Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis [J].

Carstea, ED ;

Morris, JA ;

Coleman, KG ;

Loftus, SK ;

Zhang, D ;

Cummings, C ;

Gu, J ;

Rosenfeld, MA ;

Pavan, WJ ;

Krizman, DB ;

Nagle, J ;

Polymeropoulos, MH ;

Sturley, SL ;

Ioannou, YA ;

Higgins, ME ;

Comly, M ;

Cooney, A ;

Brown, A ;

Kaneski, CR ;

BlanchetteMackie, EJ ;

Dwyer, NK ;

Neufeld, EB ;

Chang, TY ;

Liscum, L ;

Strauss, JF ;

Ohno, K ;

Zeigler, M ;

Carmi, R ;

Sokol, J ;

Markie, D ;

ONeill, RR ;

vanDiggelen, OP ;

Elleder, M ;

Patterson, MC ;

Brady, RO ;

Vanier, MT ;

Pentchev, PG ;

Tagle, DA .

SCIENCE, 1997, 277 (5323) :228-231

[6] A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis [J].

Chawla, A ;

Boisvert, WA ;

Lee, CH ;

Laffitte, BA ;

Barak, Y ;

Joseph, SB ;

Liao, D ;

Nagy, L ;

Edwards, PA ;

Curtiss, LK ;

Evans, RM ;

Tontonoz, P .

MOLECULAR CELL, 2001, 7 (01) :161-171

[7] CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors [J].

Chinetti, G ;

Gbaguidi, FG ;

Griglio, S ;

Mallat, Z ;

Antonucci, M ;

Poulain, P ;

Chapman, J ;

Fruchart, JC ;

Tedgui, A ;

Najib-Fruchart, J ;

Staels, B .

CIRCULATION, 2000, 101 (20) :2411-2417

[8] Peroxisome proliferator-activated receptor α reduces cholesterol esterification in macrophages [J].

Chinetti, G ;

Lestavel, S ;

Fruchart, JC ;

Clavey, V ;

Staels, B .

CIRCULATION RESEARCH, 2003, 92 (02) :212-217

[9] PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway [J].

Chinetti, G ;

Lestavel, S ;

Bocher, V ;

Remaley, AT ;

Neve, B ;

Torra, IP ;

Teissier, E ;

Minnich, A ;

Jaye, M ;

Duverger, N ;

Brewer, HB ;

Fruchart, JC ;

Clavey, V ;

Staels, B .

NATURE MEDICINE, 2001, 7 (01) :53-58

[10] Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation [J].

Chinetti, G ;

Fruchart, JC ;

Staels, B .

INFLAMMATION RESEARCH, 2000, 49 (10) :497-505

← 1 2 3 4 →