Antimycobacterial activity of ionic fullerene derivatives

被引：109

作者：

Bosi, S

Da Ros, T

Castellano, S

Banfi, E

Prato, M

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Univ Trieste, Dipartimento Sci Biomed, I-34127 Trieste, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)00159-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Positively charged fullerene derivatives, moderately soluble in water:DMSO 9:1, have been tested using three strains of Mycobacterium spp. Some compounds inhibit the growth of Mycobacterium tubercolosis, a human clinical isolate, particularly virulent and resistant, at doses as low as 5 mu g/mL. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1043 / 1045

页数：3

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