Do not underestimate the power of antibodies - lessons from adoptive transfer of antibodies against HIV

被引：26

作者：

Ferrantelli, F

Rasmussen, RA

Hofmann-Lehmann, R

Xu, WD

McClure, HM

Ruprecht, RM

机构：

[1] Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA

来源：

VACCINE | 2002年 / 20卷

关键词：

neutralizing antibodies; passive immunization; AIDS vaccine;

D O I：

10.1016/S0264-410X(02)00389-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prevented infection in primates, indicating that epitopes recognized by such nmAbs are key determinants for protection. Lastly, in the absence of CD8(+) T cells, nAbs may act as a second line of defense during chronic infection. Taken together, these results argue for generating nAb response-based prophylactic and/or therapeutic AIDS vaccines. We suggest that the epitopes identified by passive immunization represent excellent targets for the rational design of nAb response-based AIDS vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：A61 / A65

页数：5

共 36 条

[1] Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia [J].

Allen, TM ;

O'Connor, DH ;

Jing, PC ;

Dzuris, JL ;

Mothé, BR ;

Vogel, TU ;

Dunphy, E ;

Liebl, ME ;

Emerson, C ;

Wilson, N ;

Kunstman, KJ ;

Wang, XC ;

Allison, DB ;

Hughes, AL ;

Desrosiers, RC ;

Altman, JD ;

Wolinsky, SM ;

Sette, A ;

Watkins, DI .

NATURE, 2000, 407 (6802) :386-390

[2] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[3] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection [J].

Baba, TW ;

Liska, V ;

Hofmann-Lehmann, R ;

Vlasak, J ;

Xu, WD ;

Ayehunie, S ;

Cavacini, LA ;

Posner, MR ;

Katinger, H ;

Stiegler, G ;

Bernacky, BJ ;

Rizvi, TA ;

Schmidt, R ;

Hill, LR ;

Keeling, ME ;

Lu, YC ;

Wright, JE ;

Chou, TC ;

Ruprecht, RM .

NATURE MEDICINE, 2000, 6 (02) :200-206

[4] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].

Barouch, DH ;

Santra, S ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Wagner, W ;

Bilska, M ;

Craiu, A ;

Zheng, XX ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Nickerson, CE ;

Trigona, WL ;

Punt, K ;

Freed, DC ;

Guan, LM ;

Dubey, S ;

Casimiro, D ;

Simon, A ;

Davies, ME ;

Chastain, M ;

Strom, TB ;

Gelman, RS ;

Montefiori, DC ;

Lewis, MG ;

Emini, EA ;

Shiver, JW ;

Letvin, NL .

SCIENCE, 2000, 290 (5491) :486-492

[5] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes [J].

Barouch, DH ;

Kunstman, J ;

Kuroda, MJ ;

Schmitz, JE ;

Santra, S ;

Peyerl, FW ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Gorgone, DA ;

Montefiori, DC ;

Lewis, MG ;

Wolinsky, SM ;

Letvin, NL .

NATURE, 2002, 415 (6869) :335-339

[6] NEUTRALIZATION OF PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES BY THE BROADLY REACTIVE ANTI-V3 MONOCLONAL-ANTIBODY, 447-52D [J].

CONLEY, AJ ;

GORNY, MK ;

KESSLER, JA ;

BOOTS, LJ ;

OSSORIOCASTRO, M ;

KOENIG, S ;

LINEBERGER, DW ;

EMINI, EA ;

WILLIAMS, C ;

ZOLLAPAZNER, S .

JOURNAL OF VIROLOGY, 1994, 68 (11) :6994-7000

[7] DISQUISITIONS ON ORIGINAL ANTIGENIC SIN .I. EVIDENCE IN MAN [J].

DESTGROTH, SF ;

WEBSTER, RG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1966, 124 (03) :331-+

[8] Neutralizing antibodies against HIV - back in the major leagues? [J].

Ferrantelli, F ;

Ruprecht, RM .

CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (04) :495-502

[9]

FERRANTELLI F, IN PRESS AIDS

[10] Immunologic control of HIV-1 [J].

Gandhi, RT ;

Walker, BD .

ANNUAL REVIEW OF MEDICINE, 2002, 53 :149-172

← 1 2 3 4 →