Coumarins and anti-HBV constituents from Zanthoxylum schinifolium

Continuing examination on the chloroform-soluble part of the bark of Zanthoxylum schinifolium, two new terpenyl coumarins, 7-(5',6'-dihydroxy-3',7'-dimethylocta-2',7'-dienyloxy)-coumarin and 7-(2',6'-dihydydroxy-7'-methyl-3'-methyleneocta-7'enyloxy)-8-methoxycoumarin, along with three coumarins, anisocoumarin H, 7-[(E)-7'-hydroxy-3',7'-dimethylocta-2',5'-dienyloxy]-coumarin, scopoletin; two alkaloids, 4-methoxy-1-methyl-2-quinolone and oxynitidine and a lignan, (+)-matairesinol, were isolated as additional constituents. The structures of these compounds were elucidated by spectral analyses. Among the isolates of the bark, collinin and oxynitidine showed significant activity of anti-HBV DNA replication. (C) 1997 Elsevier Science Ltd. All rights reserved.