Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone

被引：37

作者：

Garreta, E.

Gasset, D.

Semino, C.

Borros, S.

机构：

[1] Univ Ramon Llull, Inst Quim Sarria, Barcelona Bioengn Ctr, Barcelona 08017, Spain

[2] MIT, Ctr Biomed Engn, Cambridge, MA 02139 USA

来源：

BIOMOLECULAR ENGINEERING | 2007年 / 24卷 / 01期

关键词：

cartilage; hydroxyapatite; bone tissue engineering; nanostructured composite;

D O I：

10.1016/j.bioeng.2006.05.017

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：75 / 80

页数：6

共 15 条

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