The Enrichment Study of the Minnesota Twin Family Study: Increasing the Yield of Twin Families at High Risk for Externalizing Psychopathology

被引:89
作者
Keyes, Margaret A. [1 ]
Malone, Stephen M. [1 ]
Elkins, Irene J. [1 ]
Legrand, Lisa N. [1 ]
McGue, Matt [1 ,2 ]
Iacono, William G. [1 ]
机构
[1] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA
[2] Univ So Denmark, Dept Epidemiol, Odense, Denmark
关键词
twin-family research; high-risk longitudinal designs; childhood disruptive disorders; externalizing psychopathology; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; OPPOSITIONAL DEFIANT DISORDER; ADOLESCENT SUBSTANCE USE; ILLICIT DRUG-DEPENDENCE; HIGH COGNITIVE-ABILITY; PARENT-CHILD CONFLICT; CONDUCT DISORDER; ENVIRONMENTAL-INFLUENCES; P300; AMPLITUDE;
D O I
10.1375/twin.12.5.489
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The Enrichment Study (ES) was designed to extend the Minnesota Twin Family Study (MTFS) by oversampling 11-year-old twins at especially high risk for substance use disorders by virtue of having a childhood disruptive disorder. The sample was ascertained from Minnesota birth records. To identify high-risk twins, we conducted telephone screening interviews for parent-reported symptoms of attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) as well as indications of academic disengagement. Twins who exceeded a predetermined threshold were invited to participate. To facilitate comparison with the previously ascertained MTFS participants, a random sample of 11-year-old twins was also recruited. As part of the ES study, 499 twin pairs, and their parents, visited the University of Minnesota, where each participant completed a clinical interview, psychophysiological evaluation, and thorough assessment of environmental risk. We were highly successful in recruiting at-risk twins; 52% of the screened male twins and 41% of the screened females met criteria for a diagnosis of ADHD, CD, or oppositional defiant disorder (ODD). At the pair level, 63% of the screened pairs had at least one member with a childhood disruptive disorder. This article provides an overview of the study design and includes a review of recent findings using this sample of twins.
引用
收藏
页码:489 / 501
页数:13
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