Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

被引：92

作者：

Berger, Alicia B.

Sexton, Kelly B.

Bogyo, Matthew

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Canc Biol Grad Program, Stanford, CA 94305 USA

来源：

CELL RESEARCH | 2006年 / 16卷 / 12期

关键词：

D O I：

10.1038/sj.cr.7310112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：961 / 963

页数：3

共 9 条

[1] Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes [J].

Berger, Alicia B. ;

Witte, Martin D. ;

Denault, Jean-Bernard ;

Sadaghiani, Amir Masoud ;

Sexton, Kelly M. B. ;

Salvesen, Guy S. ;

Bogyo, Matthew .

MOLECULAR CELL, 2006, 23 (04) :509-521

[2] A unified model for apical caspase activation [J].

Boatright, KM ;

Renatus, M ;

Scott, FL ;

Sperandio, S ;

Shin, H ;

Pedersen, IM ;

Ricci, JE ;

Edris, WA ;

Sutherlin, DP ;

Green, DR ;

Salvesen, GS .

MOLECULAR CELL, 2003, 11 (02) :529-541

[3] Engineered hybrid dimers:: Tracking the activation pathway of caspase-7 [J].

Denault, Jean-Bernard ;

Bekes, Miklos ;

Scott, Fiona L. ;

Sexton, Kelly M. B. ;

Bogyo, Matthew ;

Salvesen, Guy S. .

MOLECULAR CELL, 2006, 23 (04) :523-533

[4]

Jänicke RU, 2006, SCIENCE, V312, P1874

[5] Activity-based probes that target diverse cysteine protease families [J].

Kato, D ;

Boatright, KM ;

Berger, AB ;

Nazif, T ;

Blum, G ;

Ryan, C ;

Chehade, KAH ;

Salvesen, GS ;

Bogyo, M .

NATURE CHEMICAL BIOLOGY, 2005, 1 (01) :33-38

[6] Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c [J].

Liu, XS ;

Kim, CN ;

Yang, J ;

Jemmerson, R ;

Wang, XD .

CELL, 1996, 86 (01) :147-157

[7] The apoptosome activates caspase-9 by dimerization [J].

Pop, C ;

Timmer, J ;

Sperandio, S ;

Salvesen, GS .

MOLECULAR CELL, 2006, 22 (02) :269-275

[8] A combinatorial approach defines specificities of members of the caspase family and granzyme B - Functional, relationships established for key mediators of apoptosis [J].

Thornberry, NA ;

Ranon, TA ;

Pieterson, EP ;

Rasper, DM ;

Timkey, T ;

GarciaCalvo, M ;

Houtzager, VM ;

Nordstrom, PA ;

Roy, S ;

Vaillancourt, JP ;

Chapman, KT ;

Nicholson, DW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (29) :17907-17911

[9] INACTIVATION OF INTERLEUKIN-1-BETA CONVERTING-ENZYME BY PEPTIDE (ACYLOXY)METHYL KETONES [J].

THORNBERRY, NA ;

PETERSON, EP ;

ZHAO, JJ ;

HOWARD, AD ;

GRIFFIN, PR ;

CHAPMAN, KT .

BIOCHEMISTRY, 1994, 33 (13) :3934-3940

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