Triglycerides and toggling the tummy

被引：21

作者：

Kahn, CR ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

来源：

NATURE GENETICS | 2000年 / 25卷 / 01期

关键词：

D O I：

10.1038/75610

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Multiple-mechanisms regulate adipose mass and body weight. In addition to factors controlling appetite and energy expenditure, mechanisms controlling adipocyte number, triglyceride synthesis and triglyceride breakdown have important functions. But recent studies challenge our concepts concerning each of these.

引用

页码：6 / 7

页数：2

共 19 条

[1] Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes [J].

Argyropoulos, G ;

Brown, AM ;

Willi, SM ;

Zhu, JG ;

He, YF ;

Reitman, M ;

Gevao, SM ;

Spruill, I ;

Garvey, WT .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1345-1351

[2] Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations [J].

Beamer, BA ;

Yen, CJ ;

Andersen, BE ;

Muller, D ;

Elahi, D ;

Cheskin, LJ ;

Andres, R ;

Roth, J ;

Shuldiner, AR .

DIABETES, 1998, 47 (11) :1806-1808

[3] Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese [J].

Enerback, S ;

Jacobsson, A ;

Simpson, EM ;

Guerra, C ;

Yamashita, H ;

Harper, ME ;

Kozak, LP .

NATURE, 1997, 387 (6628) :90-94

[4] Obesity and the hypothalamus: Novel peptides for new pathways [J].

Flier, JS ;

Maratos-Flier, E .

CELL, 1998, 92 (04) :437-440

[5] Leptin and the regulation of body weight in mammals [J].

Friedman, JM ;

Halaas, JL .

NATURE, 1998, 395 (6704) :763-770

[6] Hormones - Leptin and diabetes in lipoatrophic mice [J].

Gavrilova, O ;

Marcus-Samuels, B ;

Leon, LR ;

Vinson, C ;

Reitman, ML .

NATURE, 2000, 403 (6772) :850-850

[7]

Hagan MM, 1999, J NEUROSCI, V19, P2362

[8] Abnormal splicing of the leptin receptor in diabetic mice [J].

Lee, GH ;

Proenca, R ;

Montez, JM ;

Carroll, KM ;

Darvishzadeh, JG ;

Lee, JI ;

Friedman, JM .

NATURE, 1996, 379 (6566) :632-635

[9] DEVELOPMENT OF OBESITY IN TRANSGENIC MICE AFTER GENETIC ABLATION OF BROWN ADIPOSE-TISSUE [J].

LOWELL, BB ;

SSUSULIC, V ;

HAMANN, A ;

LAWITTS, JA ;

HIMMSHAGEN, J ;

BOYER, BB ;

KOZAK, LP ;

FLIER, JS .

NATURE, 1993, 366 (6457) :740-742

[10] Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides [J].

Marsh, DJ ;

Hollopeter, G ;

Huszar, D ;

Laufer, R ;

Yagaloff, KA ;

Fisher, SL ;

Burn, P ;

Palmiter, RD .

NATURE GENETICS, 1999, 21 (01) :119-122

← 1 2 →