Liver Transporters in Hepatic Drug Disposition: An Update

被引：29

作者：

Li, Peng ^{[1
]}

Wang, Guang-Ji ^{[2
]}

Robertson, Thomas A. ^{[1
,3
]}

Roberts, Michael S. ^{[1
,3
]}

机构：

[1] Univ Queensland, Princess Alexandra Hosp, Therapeut Res Unit, So Clin Div, Brisbane, Qld 4102, Australia

[2] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Nanjing 210038, Peoples R China

[3] Univ S Australia, Div Hlth Sci, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia

来源：

CURRENT DRUG METABOLISM | 2009年 / 10卷 / 05期

基金：

英国医学研究理事会;

关键词：

MULTIDRUG-RESISTANCE PROTEIN; ORGANIC ANION TRANSPORTER; CHRONIC-RENAL-FAILURE; SALT EXPORT PUMP; BLOOD-BRAIN-BARRIER; TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; FAMILIAL INTRAHEPATIC CHOLESTASIS; ALTERED HEPATOBILIARY DISPOSITION; INCREASES PLASMA-CONCENTRATIONS; ISOLATED HEPATOCYTE COUPLETS;

D O I：

10.2174/138920009788898037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Drug transporters expressed on the hepatocyte membrane play an important role in hepatic drug disposition. In the last two decades, systematic research has resulted in a better understanding of the diversity, expression and substrate specificities of drug transporters in the liver. Here we review recent studies on the role of transporters in drug-drug interactions and disease states such as cirrhosis. We conclude the review by considering techniques and model systems used to study hepatic transporters, including the latest technological developments such as multiphoton microscopy.

引用

页码：482 / 498

页数：17

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