Squalene Emulsions for Parenteral Vaccine and Drug Delivery

被引：160

作者：

Fox, Christopher B. ^{[1
]}

机构：

[1] Infect Dis Res Inst, Seattle, WA 98104 USA

来源：

MOLECULES | 2009年 / 14卷 / 09期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

squalene; squalane; adjuvant; emulsion; parenteral; IN-WATER EMULSIONS; ANTHRAX VACCINE; DENDRITIC CELLS; LIPID EMULSION; OLIVE OIL; PHYSICOCHEMICAL CHARACTERIZATION; SURFACTANT CONCENTRATION; INTRAMUSCULAR INJECTION; SULFOLIPO-CYCLODEXTRIN; ADJUVANT FORMULATION;

D O I：

10.3390/molecules14093286

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.

引用

页码：3286 / 3312

页数：27

共 159 条

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ACEVEDO HF, 2002, Patent No. 2002085311

[2]

Linker-based bio-compatible microemulsions [J].