Diffusion tensor imaging of normal appearing white matter and its correlation with cognitive functioning in mild cognitive impairment and Alzheimer's disease

被引：79

作者：

Huang, Juebin ^{[1
]}

Auchus, Alexander P. ^{[1
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA

来源：

IMAGING AND THE AGING BRAIN | 2007年 / 1097卷

关键词：

mild cognitive impairment; Alzheimer's disease; diffusion tensor imaging; Wallerian degeneration;

D O I：

10.1196/annals.1379.021

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Diffusion tensor imaging (DTI) was used to examine the microstructural integrity of normal appearing White matter (NAWM) in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Significant frontal, temporal, and parietal white matter diffusion tensor changes were demonstrated in MCI and AD compared with normal controls. These changes were correlated with cognitive functioning, and are consistent with a hypothesized loss of axonal processes in affected regions.

引用

页码：259 / 264

页数：6

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