Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy

被引：36

作者：

Cvetkovic, Tatjana ^{[1
,2
]}

Mitic, Branka ^{[1
]}

Lazarevic, Gordana ^{[3
]}

Vlahovic, Predrag ^{[1
]}

Antic, Slobodan ^{[4
]}

Stefanovic, Vladisav ^{[1
]}

机构：

[1] Ctr Clin, Clin Nephrol & Hemodialysis, Nish 18000, Serbia

[2] Fac Med, Inst Biochem, Nish, Serbia

[3] Ctr Clin, Clin Cardiol, Nish, Serbia

[4] Ctr Clin, Clin Endocrinol, Nish, Serbia

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2009年 / 23卷 / 05期

关键词：

Diabetes mellitus; Diabetic nephropathy; Oxidative stress; Microalbuminuria; GLYCATION END-PRODUCTS; LIPID-PEROXIDATION; ANTIOXIDANTS; BIOMARKERS; DAMAGE; HEMODIALYSIS; EXCRETION; MELLITUS; RATS;

D O I：

10.1016/j.jdiacomp.2008.01.005

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective: Reactive oxygen species play a crucial role in the pathogenesis of diabetic nephropathy (DN). The present study was performed to assess oxidative stress parameters-thiobarbituric acid reactive substances (TBARS), reactive carbonyl derivates (RCDs), and total sulfhydryl groups (TSHGs)-in serum and urine of patients with DN. Methods: All parameters were determined in patients with type 2 and type I diabetes mellitus and microalbuminuria (DMT2-MIA, DMT1-MIA, respectively) and patients with type 2 diabetes mellitus and macroalbuminuria (DMT2-MAA) compared to healthy controls. Results: Serum and urine TBARS levels were higher in all patients with DN and microalbiminuria compared to the control group. RCD levels significantly increased in serum of patients with DMT2 relative to the controls as well as in urine of patients with DMT2-MAA and DMT1-MIA. In all groups of patients, TSHGs decreased in serum but not in urine of patients with DMT2-MAA. Conclusion: Urine TBARS, RCDs, and TSHGs could be proposed as possible markers for oxidative damage of kidney in DN. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：337 / 342

页数：6

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