Molecular mimicry in systemic lupus erythematosus

被引：35

作者：

Agmon-Levin, N. ^{[1
,2
,3
]}

Blank, M. ^{[1
,2
,3
]}

Paz, Z. ^{[1
,2
,3
]}

Shoenfeld, Y. ^{[1
,2
,3
,4
]}

机构：

[1] Chaim Sheba Med Ctr, Dept Med B, IL-52621 Tel Hashomer, Israel

[2] Chaim Sheba Med Ctr, Ctr Autoimmune Dis, IL-52621 Tel Hashomer, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[4] Tel Aviv Univ, Incumbent Laura Schwarz Kip Chair Res Autoimmune, Tel Aviv, Israel

来源：

LUPUS | 2009年 / 18卷 / 13期

关键词：

autoantibodies; autoimmunity; cross-reactivity; Epstein-Barr virus; infections; molecular mimicry; systemic lupus erythematosus; EPSTEIN-BARR-VIRUS; ANTIPHOSPHOLIPID SYNDROME; HUMORAL AUTOIMMUNITY; NUCLEAR ANTIGEN-1; AUTOANTIBODIES; ANTIBODIES; INFECTION; PEPTIDE; MICE; CYTOMEGALOVIRUS;

D O I：

10.1177/0961203309346653

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic lupus erythematosus is a multi-systemic autoimmune disease distinguished by the presence of various autoantibodies. Like most autoimmune diseases, systemic lupus erythematosus is believed to be induced by a combination of genetic, immunologic, and environmental factors, mainly infectious agents. Molecular mimicry between an infectious antigen and self-components is implicated as a pivotal mechanism by which autoimmune diseases such as systemic lupus erythematosus are triggered. Here we review the current evidence of molecular mimicry between different infectious agents and systemic lupus erythematosus. Lupus (2009) 18, 1181-1185.

引用

页码：1181 / 1185

页数：5

共 54 条

[1] Endogenous retroviruses in systemic lupus erythematosus: Candidate lupus viruses [J].

Adelman, MK ;

Marchalonis, JJ .

CLINICAL IMMUNOLOGY, 2002, 102 (02) :107-116

[2] Development of autoantibodies before the clinical onset of systemic lupus erythematosus [J].

Arbuckle, MR ;

McClain, MT ;

Rubertone, MV ;

Scofield, RH ;

Dennis, GJ ;

James, JA ;

Harley, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (16) :1526-1533

[3] Epstein-Barr virus and cytomegalovirus in autoimmune diseases - Are they truly notorious? A preliminary report [J].

Barzilai, O. ;

Sherer, Y. ;

Ram, M. ;

Izhaky, D. ;

Anaya, J. M. ;

Shoenfeld, Y. .

AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS, 2007, 1108 :567-577

[4] Phenotypic and functional analysis of EBV-specific memory CD8 cells in SLE [J].

Berner, BR ;

Tary-Lehmann, M ;

Yonkers, NL ;

Askari, AD ;

Lehmann, PV ;

Anthony, DD .

CELLULAR IMMUNOLOGY, 2005, 235 (01) :29-38

[5] Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides [J].

Blank, M ;

Shoenfeld, Y ;

Cabilly, S ;

Heldman, Y ;

Fridkin, M ;

Katchalski-Katzir, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5164-5168

[6] Antiphospholipid syndrome infectious origin [J].

Blank, M ;

Asherson, RA ;

Cervera, R ;

Shoenfeld, Y .

JOURNAL OF CLINICAL IMMUNOLOGY, 2004, 24 (01) :12-23

[7] Bacterial induction of autoantibodies to β2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome [J].

Blank, M ;

Krause, I ;

Fridkin, M ;

Keller, N ;

Kopolovic, J ;

Goldberg, I ;

Tobar, A ;

Shoenfeld, Y .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (06) :797-804

[8]

Blank M, 2007, CLIN REV ALLERG IMMU, V32, P111

[9] Human retrovirus-5 in rheumatic disease [J].

Brand, A ;

Griffiths, DJ ;

Herve, C ;

Mallon, E ;

Venables, PJW .

JOURNAL OF AUTOIMMUNITY, 1999, 13 (01) :149-154

[10] Antiphospholipid syndrome -: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients [J].

Cervera, R ;

Piette, JC ;

Font, J ;

Khamashta, MA ;

Cervera, R ;

Piette, JC ;

Font, J ;

Khamashta, MA ;

Shoenfeld, Y ;

Camps, MT ;

Jacobsen, S ;

Lakos, G ;

Tincani, A ;

Kontopoulou-Griva, I ;

Galeazzi, M ;

Meroni, PL ;

Derksen, RHWM ;

de Groot, PG ;

Gromnica-Ihle, E ;

Baleva, M ;

Mosca, M ;

Bombardieri, S ;

Houssiau, F ;

Gris, JC ;

Quéré, I ;

Hachulla, E ;

Vasconcelos, C ;

Roch, B ;

Fernández-Nebro, A ;

Boffa, MC ;

Hughes, GRV ;

Ingelmo, M .

ARTHRITIS AND RHEUMATISM, 2002, 46 (04) :1019-1027

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