Mutant Metabolic Enzymes Are at the Origin of Gliomas

被引：111

作者：

Yan, Hai ^{[1
,2
,3
]}

Bigner, Darell D. ^{[1
,2
,3
]}

Velculescu, Victor ^{[4
]}

Parsons, D. Williams ^{[4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Pediat Brain Tumor Fdn Inst, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA

[4] Johns Hopkins Kimmel Canc Ctr, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 24期

关键词：

CODON; 132; MUTATION; IDH1; MUTATIONS; DEHYDROGENASE; TUMORS; GLIOBLASTOMAS; CANCERS;

D O I：

10.1158/0008-5472.CAN-09-2650

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (11132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors. [Cancer Res 2009;69(24):9157-9]

引用

页码：9157 / 9159

页数：3

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