Lipid droplets in host-pathogen interactions

被引：18

作者：

Bozza, Patricia T. ^{[1
]}

D'Avila, Heloisa ^{[2
]}

Almeida, Patricia E. ^{[1
]}

Magalhaes, Kelly G. ^{[1
]}

Molinaro, Raphael ^{[1
]}

Almeida, Cecilia J. ^{[1
]}

Maya-Monteiro, Clarissa M. ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Imunofarmacol, BR-21045900 Rio De Janeiro, Brazil

[2] Univ Fed Juiz, Juiz, Brazil

来源：

CLINICAL LIPIDOLOGY | 2009年 / 4卷 / 06期

关键词：

eicosanoids; inflammation; intracellular pathogen; lipid bodies; lipid droplet; LPS; nuclear receptor; sepsis; tuberculosis; PROLIFERATOR-ACTIVATED RECEPTOR; DIFFERENTIATION-RELATED PROTEIN; ENDOPEROXIDE SYNTHASE CYCLOOXYGENASE; ULTRASTRUCTURAL IMMUNOGOLD LOCALIZATION; MACROPHAGE-GENE-EXPRESSION; BODY FORMATION; IN-VIVO; FATTY-ACIDS; PPAR-GAMMA; FACTOR ACETYLHYDROLASE;

D O I：

10.2217/CLP.09.63

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Increased cytoplasmic lipid droplets (also known as lipid bodies or adiposomes) in nonadipocytic cells are commonly observed pathological features of a number of infectious diseases. Although the understanding of the functional significance of lipid droplets to host-pathogen interactions and microbial pathogenesis is still very limited, great advances in this growing field have been made in the past few years. Here, we review the recent findings that are starting to uncover the molecular mechanisms that regulate lipid accumulation into lipid droplets and the functions that this organelle may play during infection, with an emphasis on the potential implications of lipid droplets on human infectious diseases.

引用

收藏

页码：791 / 807

页数：17

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