Molecular markers of prostate cancer

被引：54

作者：

Bradford, Timothy J.

Tomlins, Scott A.

Wang, Xiaoju

Chinnaiyan, Arul M. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2006年 / 24卷 / 06期

关键词：

biomarkers; prostate cancer; proteomics;

D O I：

10.1016/j.urolonc.2006.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although prostate-specific antigen (PSA) has evolved as a very useful tool for detection of prostate cancer, there remains an urgent need for more accurate biomarkers to diagnose prostate cancer and predict cancer-related outcomes. Recent advances in the study of proteomics and high throughput techniques have led to the discovery of many potential biomarkers for prostate cancer. This article briefly reviews the current status of PSA testing and discusses several candidate protein biomarkers for prostate cancer, as well as highlighting some recent proteomic discoveries with the potential to supplement or even replace PSA for the diagnosis and prognosis of prostate cancer. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：538 / 551

页数：14

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