Molecular mechanisms of blood vessel formation

被引：427

作者：

Bussolino, F

Mantovani, A

Persico, G

机构：

[1] IST RIC FARMACOL MARIO NEGRI,MILAN,ITALY

[2] UNIV BRESCIA,DIPARTIMENTO SCI BIOMED & BIOTECNOL,BRESCIA,ITALY

[3] CNR,IST INT GENET & BIOFIS,I-80125 NAPLES,ITALY

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(97)01074-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The formation of new blood vessels, angiogenesis, is a tightly regulated process. Extracellular angiogenic inducers stimulate the migration and proliferation of endothelial cells, while negative regulators counteract this effect. Changes in the relative balance of inducers and inhibitors activate the 'angiogenic switch', before stabilizer molecules activate the maturation of nascent blood vessels.

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收藏

页码：251 / 256

页数：6

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