Passerini multicomponent reaction of protected α-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors

被引：97

作者：

Banfi, L

Guanti, G

Riva, R

机构：

[1] Univ Genoa, Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

[2] CNR, CSCCCA, I-16146 Genoa, Italy

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 11期

关键词：

D O I：

10.1039/b002027n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three-component Passerini condensation of N-Boc-alpha-aminoaldehydes with various isocyanides and carboxylic acids leads, after Boc-deprotection/transacylation, to complex peptide-like structures containing an alpha-hydroxy-beta-aminoacid unit or, after oxidation, an alpha-oxo-beta-aminoacid unit.

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收藏

页码：985 / 986

页数：2

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