Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2

被引：252

作者：

Koelsch, Verena

Seher, Thomas

Fernandez-Ballester, Gregorio J.

Serrano, Luis

Leptin, Maria

机构：

[1] Univ Cologne, Inst Genet, D-50674 Cologne, Germany

[2] Univ Miguel Hernandez, Inst Biol Mol & Celular, Elche 03202, Spain

[3] European Mol Biol Lab, D-69012 Heidelberg, Germany

来源：

SCIENCE | 2007年 / 315卷 / 5810期

关键词：

D O I：

10.1126/science.1134833

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A hallmark of epithelial invagination is the constriction of cells on their apical sides. During Drosophila gastrulation, apical constrictions under the control of the transcription factor Twist lead to the invagination of the mesoderm. Twist-controlled G protein signaling is involved in mediating the invagination but is not sufficient to account for the full activity of Twist. We identified a Twist target, the transmembrane protein T48, which acts in conjunction with G protein signaling to orchestrate shape changes. Together with G protein signaling, T48 recruits adherens junctions and the cytoskeletal regulator RhoGEF2 to the sites of apical constriction, ensuring rapid and intense changes in cell shape.

引用

页码：384 / 386

页数：3

共 20 条

[1] DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo [J].