Potentiation of serum response factor activity by a family of myocardin-related transcription factors

被引：410

作者：

Wang, DZ

Li, SJ

Hockemeyer, D

Sutherland, L

Wang, ZG

Schratt, G

Richardson, JA

Nordheim, A

Olson, EN

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75390 USA

[3] Univ Tubingen, Inst Cell Biol, D-72074 Tubingen, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 23期

关键词：

D O I：

10.1073/pnas.222561499

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues.

引用

页码：14855 / 14860

页数：6

共 31 条

[1] SAP - a putative DNA-binding motif involved in chromosomal organization [J].