The Yin and Yang of CD4+ Regulatory T Cells in Autoimmunity and Cancer

被引：20

作者：

Galgani, M. ^{[2
]}

Di Giacomo, A. ^{[3
]}

Matarese, G. ^{[4
]}

La Cava, A. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Naples Federico II, Dept Cellular & Mol Biol & Pathol, Naples, Italy

[3] Azienda Osped Monaldi, Lab Cellular Immunol & Haematol, Naples, Italy

[4] CNR, Immunol Lab, IEOS, I-80125 Naples, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2009年 / 16卷 / 35期

基金：

欧洲研究理事会; 美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; DELAYED-TYPE HYPERSENSITIVITY; IMMUNOLOGICAL SELF-TOLERANCE; COLLAGEN-INDUCED ARTHRITIS; DENDRITIC CELLS; TGF-BETA; MULTIPLE-SCLEROSIS; ADOPTIVE TRANSFER; PERIPHERAL-BLOOD; SUPPRESSOR-CELLS;

D O I：

10.2174/092986709789878201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of immune homeostasis can lead to loss of tolerance to self antigens in autoimmunity, or promote unwanted tolerance to tumor growth. This review focuses on the dual activity of CD4(+) regulatory T cells (Tregs) in autoimmunity and cancer. Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer.

引用

页码：4626 / 4631

页数：6

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