Synthesis of antimalarial 1,2,4-trioxanes via photooxygenation of a chiral allylic alcohol

被引：71

作者：

Griesbeck, AG

El-Idreesy, TT

Fiege, M

Brun, R

机构：

[1] Univ Cologne, Inst Organ Chem, D-50939 Cologne, Germany

[2] Swiss Trop Inst, CH-4002 Basel, Switzerland

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 24期

关键词：

D O I：

10.1021/ol026916n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Photooxygenation of the chiral allylic alcohol 4-methyl-3-penten-2-ol (3) in nonpolar solvents and subsequent Lewis acid-catalyzed peroxyacetalization afforded a series of monocyclic and spirobicyclic 1,2,4-trioxanes (5, 6). Two products show significant anti-Malaria activity against Plasmodium falciparum when compared with chloroquine.

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收藏

页码：4193 / 4195

页数：3

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