The effects of (L)-2-oxothiazolidine-4-carboxylate on urinary oxalate excretion

被引:9
作者
Holmes, RP [1 ]
Assimos, DG [1 ]
Leaf, CD [1 ]
Whalen, JJ [1 ]
机构
[1] N CAROLINA & TRANSCEND THERAPEUT INC,CAMBRIDGE,MA
关键词
oxalates; hyperoxaluria; urinary calculi;
D O I
10.1097/00005392-199707000-00008
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: A phase I study was done to evaluate the safety and pharmacokinetics of (L)-2-oxothiazolidine-4-carboxylate (OTZ). An ancillary objective was to comp are the effects of treatment with 2 levels of OTZ to placebo on urinary oxalate excretion in healthy male subjects. Materials and Methods: Individuals underwent intravenous infusion of 70 (6) or 100 (6) mg./kg. body weight OTZ, or placebo for 2 hours at 4, 8-hour intervals. Urine was collected during the 12 hours before treatment, and at 0 to 4, 4 to 8, 8 to 24, 24 to 28, 28 to 32 and 32 to 48 hours after the initial infusion. Urine samples were assayed for creatinine, oxalate, citrate, sulfate, urate, phosphate and pH. Results: Urinary oxalate excretion relative to creatinine decreased significantly in the 100 mg./kg. dose group by 4.1 mg./gm. during the first 24 hours and by 4.6 mg./gm. in 24 to 48 hours compared to baseline values (p < 0.05). Slight decreases of 0.9 and 1.1 mg./gm., respectively, in the 70 mg./kg. dose group, and 1.6 and 2.3 mg./gm., respectively, in the placebo group were observed. Oxalate excretion on day 2 in the 100 mg./kg. dose group was significantly less than that in the placebo group (p = 0.04). Urinary pH decreased and sulfate excretion increased with OTZ therapy. Conclusions: Treatment with 100 mg./kg. OTZ every 8 hours decreases urinary oxalate excretion in healthy men.
引用
收藏
页码:34 / 37
页数:4
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