Disease State Prediction From Resting State Functional Connectivity

被引:315
作者
Craddock, R. Cameron [1 ,2 ]
Holtzheimer, Paul E., III [2 ]
Hu, Xiaoping P. [3 ]
Mayberg, Helen S. [2 ]
机构
[1] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA
[2] Emory Univ, Sch Med, Sch Psychiat & Behav Sci, Atlanta, GA USA
[3] Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA
关键词
functional connectivity; multivariate pattern analysis (MVPA); support vector classification (SVC); feature selection; disease state prediction; biomarker; major depressive disorder (MDD); SUPPORT VECTOR MACHINES; HUMAN BRAIN; FMRI DATA; COMPONENT ANALYSIS; CINGULATE CORTEX; PATTERN-ANALYSIS; SINGLE-SUBJECT; CLASSIFICATION; MRI; DEPRESSION;
D O I
10.1002/mrm.22159
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The application of multivoxel pattern analysis methods has attracted increasing attention, particularly for brain state prediction and real-time functional MRI applications. Support vector classification is the most popular of these techniques, owing to reports that it has better prediction accuracy and is less sensitive to noise. Support vector classification was applied to learn functional connectivity patterns that distinguish patients with depression from healthy volunteers. In addition, two feature selection algorithms were implemented (one filter method, one wrapper method) that incorporate reliability information into the feature selection process. These reliability feature selections methods were compared to two previously proposed feature selection methods. A support vector classifier was trained that reliably distinguishes healthy volunteers from clinically depressed patients. The reliability feature selection methods outperformed previously utilized methods. The proposed framework for applying support vector classification to functional connectivity data is applicable to other disease states beyond major depression. Magn Reson Med 62: 1619-1628, 2009. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:1619 / 1628
页数:10
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