The Myc oncoprotein as a therapeutic target for human cancer

被引：449

作者：

Vita, Marina ^{[1
]}

Henriksson, Marie ^{[1
]}

机构：

[1] Karolinska Inst, Dept MTC, SE-17177 Stockholm, Sweden

来源：

SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 04期

关键词：

transcription; proliferation; apoptosis; differentiation; tumorigenesis; cancer therapy;

D O I：

10.1016/j.semcancer.2006.07.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myc expression is deregulated in a wide range of human cancers and is often associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell-cycle progression, transcription, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the growth promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we give an overview of Myc activation in human tumors and discuss current strategies aimed at targeting Myc for cancer treatment. Such therapies could have potential in combination with mechanistically different cytotoxic drugs to combat and eradicate tumors cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：318 / 330

页数：13

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