Role of plant glyoxylate reductases during stress: a hypothesis

被引：77

作者：

Allan, Wendy L. ^{[1
]}

Clark, Shawn M. ^{[1
]}

Hoover, Gordon J. ^{[1
]}

Shelp, Barry J. ^{[1
]}

机构：

[1] Univ Guelph, Dept Plant Agr, Guelph, ON N1G 2W1, Canada

来源：

BIOCHEMICAL JOURNAL | 2009年 / 423卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

aldehyde detoxification; glyoxylate reductase; beta-hydroxyacid dehydrogenase; redox balance; succinic semialdehyde reductase; SUCCINIC-SEMIALDEHYDE DEHYDROGENASE; GAMMA-AMINOBUTYRIC-ACID; DEPENDENT NAD(+) KINASE; GABA SHUNT; NADH KINASE; FUNCTIONAL-CHARACTERIZATION; NITRATE ASSIMILATION; PYRIDINE-NUCLEOTIDES; LIPID-PEROXIDATION; REDUCED ACTIVITIES;

D O I：

10.1042/BJ20090826

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular modelling suggests that a group of proteins in plants known as the beta-hydroxyacid dehydrogenases, or the hydroxyisobutyrate dehydrogenase superfamily, includes enzymes that reduce succinic semialdehyde and glyoxylate to gamma-hydroxybutyrate and glycolate respectively. Recent biochemical and expression studies reveal that NADPH-dependent cytosolic (termed GLYR1) and plastidial (termed GLYR2) isoforms of succinic semialdehyde/glyoxylate reductase exist in Arabidopsis. Succinic semialdehyde and glyoxylate are typically generated in leaves via two distinct metabolic pathways, gamma-aminobutyrate and glycolate respectively. In the present review, it is proposed that the GLYRs function in the detoxification of both aldehydes during stress and contribute to redox balance. Outstanding questions are highlighted in a scheme for the subcellular organization of the detoxification mechanism in Arabidopsis.

引用

页码：15 / 22

页数：8

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