Association between the hypertriglyceridemic waist phenotype and hyperuricemia: a cross-sectional study

The present study aimed to evaluate the relationship between the hypertriglyceridemic waist (HTGW) phenotype and hyperuricemia. We undertook a cross-sectional study with a sample of 11,576 adults from China. The HTGW phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Logistic regression analysis was used to evaluate the association between the HTGW phenotype and hyperuricemia. The prevalence of hyperuricemia was significantly higher in individuals with the HTGW phenotype, as compared to those with the normal waist normal triglyceride (NWNT) group (25.9 vs. 6.1%, respectively, P < 0.001). After adjusting for age, sex, and race, the HTGW phenotype was associated with hyperuricemia (OR 6.09; 95% CI 5.18-7.17). Further adjusted for potential confounders, the HTGW phenotype was still significantly associated with hyperuricemia (adjusted OR 4.54; 95% CI 3.37-5.54). Moreover, the association between the HTGW phenotype and hyperuricemia was stronger in men (adjusted OR 4.59; 95% CI 3.53-5.98) than in women (adjusted OR 3.55; 95% CI 2.60-4.86). This study indicated that the HTGW phenotype was strongly associated with hyperuricemia, and uric acid should be clinically monitored in individuals with the HTGW phenotype. We can speculate that the HTGW phenotype might be a marker for identifying individuals at high risk of hyperuricemia.