1 alpha,25-dihydroxyvitamin D-3 induces very low density lipoprotein receptor mRNA expression in HL-60 cells in association with monocytic differentiation

被引：17

作者：

Kohno, M ^{[1
]}

Takahashi, S ^{[1
]}

Oida, K ^{[1
]}

Suzuki, J ^{[1
]}

Tamai, T ^{[1
]}

Yamamoto, T ^{[1
]}

Nakai, T ^{[1
]}

机构：

[1] TOHOKU UNIV,CTR GENE RES,SENDAI,MIYAGI 981,JAPAN

来源：

ATHEROSCLEROSIS | 1997年 / 133卷 / 01期

关键词：

VLDL receptor; HL-60; cells; monocytic cells; macrophages; cell differentiation; 1; alpha; 25-dihydroxyvitamin D-3;

D O I：

10.1016/S0021-9150(97)00112-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Expression of VLDL receptor mRNA during differentiation of HL-60 cells was investigated by Northern analysis. The expression induced in 1 alpha,25-dihydroxyvitamin D-3 (1 alpha,25(OH)(2)D-3)-treated cells was 3 times that in untreated cells, while LDL receptor mRNA expression was unchanged. VLDL receptor mRNA levels were not changed in macrophages caused to differentiate from HL-60 cells by treatment with phorbol 12-myristate 13-adetate (PMA). Treatment of sarcoma cells which possess the vitamin D receptor (MG-63 cell line) with 1 alpha,25(OH)(2)D-3 did not affect VLDL receptor- mRNA levels. Therefore, 1 alpha,25(OH)(2)D-3 induces VLDL receptor mRNA in HL-60 cells through differentiation-dependent mechanisms. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：45 / 49

页数：5

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